Due to high prevalence of breast cancer in females, there are annually lots of breast surgical operations for removal of malignant tumors. However, failure in discovery and removal of cancerous lymph nodes will lead to metastasis of cancer in the patient. Currently, there are some methods with different degrees of accuracy, cost, and ease to detect sentinel nodes. Amongst all of them, the most common and the most favorite device for surgeons is “Gamma Probe” providing an easy-to-use small hand-held tool with the capability of detection and localization of sentinel lymph nodes not only in breast cancer but also for some masculine types of cancers where detection of sentinel nodes is mandatory. We developed such a gamma probe system in two models: SURGEOGUIDE and SURGEOGUIDE II. Both models passed international certificates and have Iran MOH production license.